var hbsMd5 = require('handlebars-md5');
Handlebars.registerHelper('md5', hbsMd5);
 
var template = Handlebars.compile('<script src="/assets/js/require-{{md5 "public/assets/js/require.js"}}.js"></script>');
template.render(); // <script src="/assets/js/require-498527f993c7f7052a542191159a6781.js"></script>